Cobalt(I)-catalyzed asymmetric [2+2+2] cycloaddition of alkynes and nitriles: Synthesis of enantiomerically enriched atropoisomers of 2-arylpyridines

被引：233

作者：

Gutnov, A

Heller, B

Fischer, C

Drexler, HJ

Spannenberg, A

Sundermann, B

Sundermann, C

机构：

[1] Univ Rostock eV, Leibniz Inst Organ Katalyse, D-18055 Rostock, Germany

[2] Univ Rostock eV, Leibniz Inst Organ Katalyse, D-52099 Aachen, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 29期

关键词：

asymmetric catalysis; atropoisomerism; cobalt; cyclotrimerization; nitrogen heterocycles;

D O I：

10.1002/anie.200454164

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new flavor of chiral induction in the [2+2+2] cycloaddition yielding pyridines: Atropoisomers were prepared in the reaction of alkynes and nitriles in the presence of 1 mol % chiral Co1 catalysts such as 1 with high yields and up to 93% ee.

引用

页码：3795 / 3797

页数：3

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