Turning ecology and evolution against cancer

被引:199
作者
Korolev, Kirill S. [1 ]
Xavier, Joao B. [2 ]
Gore, Jeff [3 ]
机构
[1] Boston Univ, Bioinformat Program, Boston, MA 02215 USA
[2] Mem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10021 USA
[3] MIT, Cambridge, MA 02139 USA
基金
美国国家卫生研究院;
关键词
IMMUNODEFICIENCY-VIRUS-INFECTION; PASSENGER MUTATIONS; ANTIBIOTIC-RESISTANCE; CLONAL INTERFERENCE; ESCHERICHIA-COLI; CONTROLLED-TRIAL; MULLERS RATCHET; DRUG-RESISTANCE; GENETIC DRIFT; LIFE-HISTORY;
D O I
10.1038/nrc3712
中图分类号
R73 [肿瘤学];
学科分类号
100214 [肿瘤学];
摘要
The fight against cancer has drawn researchers from a wide variety of disciplines, ranging from molecular biology to physics, but the perspective of an ecological theorist has been mostly overlooked. By thinking about the cells that make up a tumour as an endangered species, cancer vulnerabilities become more apparent. Studies in conservation biology and microbial experiments indicate that extinction is a complex phenomenon, which is often driven by the interaction of ecological and evolutionary processes. Recent advances in cancer research have shown that tumours, like species striving for survival, harbour intricate population dynamics, which suggests the possibility to exploit the ecology of tumours for treatment.
引用
收藏
页码:371 / 380
页数:10
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