Type I interferons and the Th1/Th2 paradigm

被引：56

作者：

Sinigaglia, F ^{[1
]}

D'Ambrosio, D ^{[1
]}

Rogge, L ^{[1
]}

机构：

[1] Roche Milano Ric, I-20132 Milan, Italy

来源：

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 1999年 / 23卷 / 7-8期

关键词：

Th1; cells; Th2; IL-12; interferon; cytokine signalling; multiple sclerosis;

D O I：

10.1016/S0145-305X(99)00039-7

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

During the past year significant advances have been made in our understanding of the factors contributing to the differentiation of CD4(+) T helper cell subsets. These have been driven, in part, by the realization that cytokines from the innate immune response, such as interleukin-12. (IL-12) and interferons (IFNs), play a critical role in T cell subset differentiation. This review covers some of the most recent data concerning the divergent role that IFNs have in the differentiation of human versus mouse T helper cell subsets. In this review we discuss the molecular basis for the specie-specific effect of type I IFN on the selective induction of Th1 type immune responses. Furthermore, since IFN-beta is used in the treatment of multiple sclerosis (MS) we discuss the potential effects of such treatment and the value of the Th1/Th2 paradigm in MS. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：657 / 663

页数：7

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