N-thiolated β-lactams:: Novel antibacterial agents for methicillin-resistant Staphylococcus aureus

被引：44

作者：

Turos, E

Long, TE

Konaklieva, MI

Coates, C

Shim, JY

Dickey, S

Lim, DV

Cannons, A

机构：

[1] Univ S Florida, Dept Chem, Tampa, FL 33620 USA

[2] Univ S Florida, Dept Biol, Tampa, FL 33620 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 16期

关键词：

D O I：

10.1016/S0960-894X(02)00343-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

In this report we describe a new family of N-thiolated beta-lactams that have antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). The compounds show unprecedented structure-activity features and an unusual mode of action for a beta-lactam antibiotic. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2229 / 2231

页数：3

共 8 条

[1]

Emerging infectious diseases: Public health issues for the 21st century [J].