Novel three-step synthesis of (-(+)over-bar)-harmicine

被引：46

作者：

Knölker, HJ ^{[1
]}

Agarwal, S ^{[1
]}

机构：

[1] Tech Univ Dresden, Inst Organ Chem, D-01069 Dresden, Germany

来源：

SYNLETT | 2004年 / 10期

关键词：

alkaloids; cyclizations; hydrogenations; pyrroles; nucleophilic additions;

D O I：

10.1055/s-2004-830856

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A three-step synthesis of (+/-)-harmicine from 3,4-dihydro-beta-carboline is achieved by addition of a 3-trimethylsilylpropargyl Grignard reagent, Ag(I)-promoted oxidative cyclization to a pyrrole, and chemoselective hydrogenation of the pyrrole ring.

引用

页码：1767 / 1768

页数：2

共 25 条

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