Asymmetric direct aldol reaction assisted by water and a proline-derived tetrazole catalyst

被引：556

作者：

Torii, H

Nakadai, M

Ishihara, K

Saito, S ^{[1
]}

Yamamoto, H

机构：

[1] Nagoya Univ, Inst Adv Res, Nagoya, Aichi 4648602, Japan

[2] Nagoya Univ, Grad Sch Sci, Nagoya, Aichi 4648602, Japan

[3] Univ Chicago, Dept Chem, Chicago, IL 60637 USA

[4] Nagoya Univ, Grad Sch Engn, Nagoya, Aichi 4648603, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 15期

关键词：

aldol reaction; amines; asymmetric catalysis; tetrazole; water;

D O I：

10.1002/anie.200352724

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Just add water to improve the performance of direct aldol reactions like that shown. Previously, aldehydes with high water-affinity or -solubility were considered unsuitable for asymmetric synthesis.

引用

页码：1983 / 1986

页数：4

共 60 条

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