Biomechanopharmacology: a new borderline discipline

被引:34
作者
Liao, Fulong [1 ]
Li, Min
Han, Dong
Cao, Jun
Chen, Keji
机构
[1] Chinese Acad Tradit Chinese Med, Inst Chinese Mat Med, Beijing 100700, Peoples R China
[2] China Japan Friendship Hosp, Natl Cardiovasc Ctr Integrated Tradit Chinese & W, Beijing 100029, Peoples R China
[3] Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China
[4] Natl Ctr Nanosci & Technol, Beijing 100080, Peoples R China
关键词
D O I
10.1016/j.tips.2006.04.001
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Flowing blood is more than a drug transporter in pharmacology; its mechanical impact should also be considered. The in vitro pharmacological dose-response pattern of endothelial cellular functions can be significantly modified by in vivo shear stress. A new borderline discipline, biomechanopharmacology, is forming at the boundary between biomechanics and pharmacology. Biomechanopharmacology will probably consist of both the pharmacological intervention of signals induced by biomechanical factors and the biomechanical influence on pharmacokinetics and pharmacodynamics, in addition to the joint effect of biomechanical and pharmacological factors. Recent investigations show that exercise enhances the shear of pulsatile blood flow to stimulate angiogenesis. The benefits of exercise for gaining joint biomechanical and pharmacological effects should be emphasized.
引用
收藏
页码:287 / 289
页数:3
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