Hematopoietic Cytokines Can Instruct Lineage Choice

被引：304

作者：

Rieger, Michael A. ^{[1
]}

Hoppe, Philipp S. ^{[1
]}

Smejkal, Benjamin M. ^{[1
]}

Eitelhuber, Andrea C. ^{[1
]}

Schroeder, Timm ^{[1
]}

机构：

[1] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Stem Cell Res, Neuherberg, Germany

来源：

SCIENCE | 2009年 / 325卷 / 5937期

关键词：

STIMULATING FACTOR-RECEPTOR; CELLS; COMMITMENT; MACROPHAGE; DIFFERENTIATION; GRANULOCYTE; PROGENITORS; EXPRESSION;

D O I：

10.1126/science.1171461

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The constant regeneration of the blood system during hematopoiesis requires tightly controlled lineage decisions of hematopoietic progenitor cells (HPCs). Because of technical limitations, differentiation of individual HPCs could not previously be analyzed continuously. It was therefore disputed whether cell-extrinsic cytokines can instruct HPC lineage choice or only allow survival of cells that are already lineage-restricted. Here, we used bioimaging approaches that allow the continuous long-term observation of individual differentiating mouse HPCs. We demonstrate that the physiological cytokines, macrophage colony-stimulating factor and granulocyte colony-stimulating factor, can instruct hematopoietic lineage choice.

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页码：217 / 218

页数：2

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