MSY2:: a slowly evolving minisatellite on the human Y chromosome which provides a useful polymorphic marker in Chinese populations

被引：20

作者：

Bao, WD

Zhu, SL

Pandya, A

Zerjal, T

Xu, JJ

Shu, QF

Du, RF

Yang, HM

Tyler-Smith, C

机构：

[1] Univ Oxford, Dept Biochem, Oxford OX1 3QU, England

[2] Chinese Acad Sci, Inst Genet, Beijing 100101, Peoples R China

来源：

GENE | 2000年 / 244卷 / 1-2期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会; 中国国家自然科学基金;

关键词：

ape; DNA polymorphism; human diversity; human evolution; male lineage;

D O I：

10.1016/S0378-1119(00)00021-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We present the second human Y-specific minisatellite, MSY2 (DYS440). It consists of three or four copies of a 99-110 bp repeat unit and is located about 1 kb upstream of the DBY gene. The most common allele contains four units, but a three-unit allele has arisen on at least four occasions; ill chimpanzees and orangutans, MSY2 contains only two units. It is therefore evolving slowly and provides a particularly useful polymorphic marker for Chinese populations. (C) 2000 Published by Elsevier Science B.V. All rights reserved.

引用

收藏

页码：29 / 33

页数：5

相关论文

共 22 条

[1] Novel mutation processes in the evolution of a haploid minisatellite, MSY1: array homogenization without homogenization [J].

Bouzekri, N ;

Taylor, PG ;

Hammer, MF ;

Jobling, MA .

HUMAN MOLECULAR GENETICS, 1998, 7 (04) :655-659

[2] STRUCTURE OF THE PERICENTRIC LONG ARM REGION OF THE HUMAN Y-CHROMOSOME [J].

COOPER, KF ;

FISHER, RB ;

TYLERSMITH, C .

JOURNAL OF MOLECULAR BIOLOGY, 1992, 228 (02) :421-432

[3] Chromosome Y microsatellites: Population genetic and evolutionary aspects [J].

deKnijff, P ;

Kayser, M ;

Caglia, A ;

Corach, D ;

Fretwell, N ;

Gehrig, C ;

Graziosi, G ;

Heidorn, F ;

Herrmann, S ;

Herzog, B ;

Hidding, M ;

Honda, K ;

Jobling, M ;

Krawczak, M ;

Leim, K ;

Meuser, S ;

Meyer, E ;

Oesterreich, W ;

Pandya, A ;

Parson, W ;

Penacino, G ;

PerezLezaun, A ;

Piccinini, A ;

Prinz, M ;

Schmitt, C ;

Schneider, PM ;

Szibor, R ;

TeifelGreding, J ;

Weichhold, G ;

Roewer, L .

INTERNATIONAL JOURNAL OF LEGAL MEDICINE, 1997, 110 (03) :134-149

[4] Jefferson fathered slave's last child [J].

Foster, EA ;

Jobling, MA ;

Taylor, PG ;

Donnelly, P ;

de Knijff, P ;

Mieremet, R ;

Zerjal, T ;

Tyler-Smith, C .

NATURE, 1998, 396 (6706) :27-28

[5] EVOLUTIONARY TRANSIENCE OF HYPERVARIABLE MINISATELLITES IN MAN AND THE PRIMATES [J].

GRAY, IC ;

JEFFREYS, AJ .

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1991, 243 (1308) :241-253

[6]

Hammer MF, 1997, GENETICS, V145, P787

[7] A RECENT COMMON ANCESTRY FOR HUMAN-Y-CHROMOSOMES [J].

HAMMER, MF .

NATURE, 1995, 378 (6555) :376-378

[8] COMPLEX GENE CONVERSION EVENTS IN GERMLINE MUTATION AT HUMAN MINISATELLITES [J].

JEFFREYS, AJ ;

TAMAKI, K ;

MACLEOD, A ;

MONCKTON, DG ;

NEIL, DL ;

ARMOUR, JAL .

NATURE GENETICS, 1994, 6 (02) :136-145

[9] REPEAT UNIT SEQUENCE VARIATION IN MINISATELLITES - A NOVEL SOURCE OF DNA POLYMORPHISM FOR STUDYING VARIATION AND MUTATION BY SINGLE MOLECULE ANALYSIS [J].

JEFFREYS, AJ ;

NEUMANN, R ;

WILSON, V .

CELL, 1990, 60 (03) :473-485

[10] HYPERVARIABLE MINISATELLITE REGIONS IN HUMAN DNA [J].

JEFFREYS, AJ ;

WILSON, V ;

THEIN, SL .

NATURE, 1985, 314 (6006) :67-73