Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation

被引：162

作者：

Fu, Lei ^{[1
,4
]}

Yun, Francisco ^{[1
]}

Oczak, Marko ^{[1
]}

Wong, Betty Y. L. ^{[4
]}

Vieth, Reinhold ^{[1
,5
]}

Cole, David E. C. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5G 1L5, Canada

[2] Univ Toronto, Dept Pediat Genet, Toronto, ON M5G 1L5, Canada

[3] Univ Toronto, Dept Med, Toronto, ON M5G 1L5, Canada

[4] Sunnybrook Hlth Sci Ctr, Dept Clin Pathol, Toronto, ON M4N 3M5, Canada

[5] Mt Sinai Hosp, Dept Pathol & Lab Med, Toronto, ON M5G 1X5, Canada

来源：

CLINICAL BIOCHEMISTRY | 2009年 / 42卷 / 10-11期

关键词：

Vitamin D binding protein; Single nucleotide polymorphisms; Genotype; Serum 25(OH)D; Vitamin D supplementation; PLASMA-CONCENTRATIONS; POSTMENOPAUSAL WOMEN; PARATHYROID-HORMONE; GC; 1,25-DIHYDROXYVITAMIN-D;

D O I：

10.1016/j.clinbiochem.2009.03.008

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: To determine the effect of vitamin D binding protein (DBP) genotypes on 25-hydroxyvitamin D [25(OH)D] changes with vitamin D supplements, we studied 98 adults receiving 600 or 4000 IU/d vitamin D-3 for one year. Methods: The DBP functional variant, T436K, was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: Mean 25(OH)D increases were 97% for TT (n=48) 151% for TK (n=31) and 307% (n=6) for KK genotypes (P=.004). Conclusions: As with baseline 25(OH)D, T436K genotype predicts 25(OH)D changes after long-term vitamin D supplementation. (C) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：1174 / 1177

页数：4

共 10 条

[1]

ARNAUD J, 1993, HUM GENET, V92, P183

[2]

BRAUN A, 1992, HUM GENET, V89, P401

[3] Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans [J].

Engelman, Corinne D. ;

Fingerlin, Tasha E. ;

Langefeld, Carl D. ;

Hicks, Pamela J. ;

Rich, Stephen S. ;

Wagenknecht, Lynne E. ;

Bowden, Donald W. ;

Norris, Jill M. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (09) :3381-3388

[4] Genetic contribution to bone metabolism, calcium excretion, and vitamin D and parathyroid hormone regulation [J].

Hunter, D ;

De Lange, M ;

Snieder, H ;

MacGregor, AJ ;

Swaminathan, R ;

Thakker, RV ;

Spector, TD .

JOURNAL OF BONE AND MINERAL RESEARCH, 2001, 16 (02) :371-378

[5] ETHNIC VARIATION IN VITAMIN-D-BINDING PROTEIN (GC) - A REVIEW OF ISOELECTRIC-FOCUSING STUDIES IN HUMAN-POPULATIONS [J].

KAMBOH, MI ;

FERRELL, RE .

HUMAN GENETICS, 1986, 72 (04) :281-293

[6] Plasma concentrations of 25-hydroxy-vitamin D and 1,25-dihydroxy-vitamin D are related to the phenotype of Gc (vitamin D-binding protein): A cross-sectional study on 595 - Early postmenopausal women [J].

Lauridsen, AL ;

Vestergaard, P ;

Hermann, AP ;

Brot, C ;

Heickendorff, L ;

Mosekilde, L ;

Nexo, E .

CALCIFIED TISSUE INTERNATIONAL, 2005, 77 (01) :15-22

[7] The relationship between vitamin D and parathyroid hormone: calcium homeostasis, bone turnover, and bone mineral density in postmenopausal women with established osteoporosis [J].

Sahota, O ;

Mundey, MK ;

San, P ;

Godber, IM ;

Lawson, N ;

Hosking, DJ .

BONE, 2004, 35 (01) :312-319

[8] Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women [J].

Sinotte, Marc ;

Diorio, Caroline ;

Berube, Sylvie ;

Pollak, Michael ;

Brisson, Jacques .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2009, 89 (02) :634-640

[9] Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism [J].

Speeckaert, Marijn ;

Huang, Guangming ;

Delanghe, Joris R. ;

Taes, Youri E. C. .

CLINICA CHIMICA ACTA, 2006, 372 (1-2) :33-42

[10]

VIETH R, 1994, CLIN CHEM, V40, P435

← 1 →