Treatment of extensive chronic cutaneous graftversus-host disease in an infant with topical pimecrolimus

被引：24

作者：

Ziemer, M

Gruhn, B

Thiele, JJ

Elsner, P

机构：

[1] Univ Jena, Dept Dermatol, D-6900 Jena, Germany

[2] Univ Jena, Dept Pediat, D-6900 Jena, Germany

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2004年 / 50卷 / 06期

关键词：

D O I：

10.1016/j.jaad.2004.02.010

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We report a case of generalized cutaneous chronic graft-versus-host disease in a 17-month-old infant. Topical treatment with the novel ascomycin substance pimecrolimus once daily for 4 weeks led to a near complete clearance of skin lesions. Importantly, this excellent clinical response was obtained without additional use of systemic immunosuppressive treatment.

引用

收藏

页码：946 / 948

页数：3

相关论文

共 17 条

[1]

Billich A, 2002, J INVEST DERMATOL, V119, P346

[2]

BILLICH A, 2002, J EUR ACAD DERMATOL, V16, P257

[3] IMMUNOPATHOLOGY OF CUTANEOUS GRAFT-VERSUS-HOST DISEASE [J].

BREATHNACH, SM ;

KATZ, SI .

AMERICAN JOURNAL OF DERMATOPATHOLOGY, 1987, 9 (04) :343-348

[4]

Choi CJ, 2001, ARCH DERMATOL, V137, P1202

[5]

FERRARA JLM, 1991, NEW ENGL J MED, V324, P667

[6] Psoralen and ultraviolet A irradiation (PUVA) as therapy for steroid-resistant cutaneous acute graft-versus-host disease [J].

Furlong, T ;

Leisenring, W ;

Storb, R ;

Anasetti, C ;

Appelbaum, FR ;

Carpenter, PA ;

Deeg, HJ ;

Doney, K ;

Kiem, HP ;

Nash, RA ;

Sanders, JE ;

Witherspoon, R ;

Thompson, D ;

Martin, PJ .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2002, 8 (04) :206-212

[7] Narrowband UV-B phototherapy in the treatment of cutaneous graft versus host disease [J].

Grundmann-Kollmann, M ;

Martin, H ;

Ludwig, R ;

Klein, S ;

Boehncke, WH ;

Hoelzer, D ;

Kaufmann, R ;

Podda, M .

TRANSPLANTATION, 2002, 74 (11) :1631-1634

[8] Chronic sclerodermic graft-versus-host disease refractory to immunosuppressive treatment responds to UVA1 phototherapy [J].

Grundmann-Kollmann, M ;

Behrens, S ;

Gruss, C ;

Gottlöber, P ;

Peter, RU ;

Kerscher, M .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2000, 42 (01) :134-136

[9] GRAFT VERSUS HOST REACTION - CUTANEOUS MANIFESTATIONS FOLLOWING BONE-MARROW TRANSPLANTATION [J].

HOOD, AF ;

SOTER, NA ;

RAPPEPORT, J ;

GIGLI, I .

ARCHIVES OF DERMATOLOGY, 1977, 113 (08) :1087-1091

[10]

Horn TD, 1999, BRIT J DERMATOL, V141, P779