The structural basis of elasticity in fibrillin-based microfibrils

被引:3
作者
Arnaout, MA [1 ]
机构
[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Renal Unit, Boston, MA 02114 USA
[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Struct Biol Program, Boston, MA 02114 USA
关键词
D O I
10.1016/j.str.2004.04.005
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The resiliency of vertebrate tissues such as skin and blood vessels is generated by the elastic fiber network. A recent article by Lee and colleagues (Lee et al., 2004) provides intriguing new cues into the organization and structure of this network.
引用
收藏
页码:734 / 736
页数:3
相关论文
共 9 条
[1]   The supramolecular organization of fibrillin-rich microfibrils [J].
Baldock, C ;
Koster, AJ ;
Ziese, U ;
Rock, MJ ;
Sherratt, MJ ;
Kadler, KE ;
Shuttleworth, CA ;
Kielty, CM .
JOURNAL OF CELL BIOLOGY, 2001, 152 (05) :1045-1056
[2]   Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by α5β1 and αvβ3 integrins [J].
Bax, DV ;
Bernard, SE ;
Lomas, A ;
Morgan, A ;
Humphries, J ;
Shuttleworth, CA ;
Humphries, MJ ;
Kielty, CM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (36) :34605-34616
[3]   Integrins: Bidirectional, allosteric signaling machines [J].
Hynes, RO .
CELL, 2002, 110 (06) :673-687
[4]   Structure of the integrin binding fragment from fibrillin-1 gives new insights into microfibril organization [J].
Lee, SSJ ;
Knott, V ;
Jovanovic, J ;
Harlos, K ;
Grimes, JM ;
Choulier, L ;
Mardon, HJ ;
Stuart, DI ;
Handford, PA .
STRUCTURE, 2004, 12 (04) :717-729
[5]   The molecular genetics of Marfan syndrome and related microfibrillopathies [J].
Robinson, PN ;
Godfrey, M .
JOURNAL OF MEDICAL GENETICS, 2000, 37 (01) :9-25
[6]   Fibrillin microfibrils are stiff reinforcing fibres in compliant tissues [J].
Sherratt, MJ ;
Baldock, C ;
Haston, JL ;
Holmes, DF ;
Jones, CJP ;
Shuttleworth, CA ;
Wess, TJ ;
Kielty, CM .
JOURNAL OF MOLECULAR BIOLOGY, 2003, 332 (01) :183-193
[7]   Crystal structure of the extracellular segment of integrin αVβ3 in complex with an Arg-Gly-Asp ligand [J].
Xiong, JP ;
Stehle, T ;
Zhang, RG ;
Joachimiak, A ;
Frech, M ;
Goodman, SL ;
Arnaout, MA .
SCIENCE, 2002, 296 (5565) :151-155
[8]   Effects of the N2144S mutation on backbone dynamics of a TB-cbEGF domain pair from human fibrillin-1 [J].
Yuan, XM ;
Werner, JM ;
Lack, J ;
Knott, V ;
Handford, PA ;
Campbell, ID ;
Downing, AK .
JOURNAL OF MOLECULAR BIOLOGY, 2002, 316 (01) :113-125
[9]   DEVELOPMENTAL EXPRESSION OF FIBRILLIN GENES SUGGESTS HETEROGENEITY OF EXTRACELLULAR MICROFIBRILS [J].
ZHANG, H ;
HU, W ;
RAMIREZ, F .
JOURNAL OF CELL BIOLOGY, 1995, 129 (04) :1165-1176