This paper is the second of two and presents a planning methodology for low-voltage distribution network planning. Combined optimization of transformers and associated networks is applied, considering the street layout which connects the different consumers. In the first section, a planning zone division into smaller mini-zones is performed; the smaller zones are optimized independently. This second section develops macro-optimization methodologies that use the results and techniques of the previous stage, which allow performing a global analysis of the planning zone. Three methodologies are proposed, one based on Voronoi polygons to obtain irregular mini-zones that incorporate proximity between consumers. Another is based on network recombination, with the purpose of finding potential savings produced by combining neigh-boring networks. Lastly, the sequential application of Voronoi polygons and network recombination is performed. The methodology is applied to a zone having 20215 consumers distributed in an area of 12.9 km(2) corresponding to a district in the city of Santiago, Chile, to subsequently apply this to the entire city, an area having a surface of 2118 km(2) and approximately 1300 000 customers.