Comparison of the host responses to wild-type and cpsB mutant Klebsiella pneumoniae infections

被引：74

作者：

Lawlor, Matthew S.

Handley, Scott A.

Miller, Virginia L.

机构：

[1] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA

来源：

INFECTION AND IMMUNITY | 2006年 / 74卷 / 09期

关键词：

D O I：

10.1128/IAI.00244-06

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Previously, we established an intranasal mouse model of Klebsiella pneumoniae infection and validated its utility using a highly virulent wild-type strain and an avirulent capsular polysaccharide mutant. In the present study we compare the host responses to both infections by examining cytokine production, cellular infiltration, pulmonary histology, and intranasal immunization.

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页码：5402 / 5407

页数：6

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