Cardiovascular risk factors and future risk of Alzheimer's disease

被引：247

作者：

de Bruijn, Renee F. A. G. ^{[1
,2
]}

Ikram, M. Arfan ^{[1
,2
,3
]}

机构：

[1] Erasmus MC Univ Med Ctr, Dept Epidemiol, NL-3015 CN Rotterdam, Netherlands

[2] Erasmus MC Univ Med Ctr, Dept Neurol, NL-3015 CE Rotterdam, Netherlands

[3] Erasmus MC Univ Med Ctr, Dept Radiol, NL-3015 CE Rotterdam, Netherlands

来源：

BMC MEDICINE | 2014年 / 12卷

关键词：

Cardiovascular disease; Imaging markers; Risk factors; Dementia; Alzheimer's disease; MILD COGNITIVE IMPAIRMENT; CHRONIC KIDNEY-DISEASE; WHITE-MATTER LESIONS; LATE-LIFE DEMENTIA; MIDLIFE BLOOD-PRESSURE; SILENT BRAIN INFARCTS; SMALL VESSEL DISEASE; BODY-MASS INDEX; PHYSICAL-ACTIVITY; ATRIAL-FIBRILLATION;

D O I：

10.1186/s12916-014-0130-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Alzheimer's disease (AD) is the most common neurodegenerative disorder in elderly people, but there are still no curative options. Senile plaques and neurofibrillary tangles are considered hallmarks of AD, but cerebrovascular pathology is also common. In this review, we summarize findings on cardiovascular disease (CVD) and risk factors in the etiology of AD. Firstly, we discuss the association of clinical CVD (such as stroke and heart disease) and AD. Secondly, we summarize the relation between imaging makers of pre-clinical vascular disease and AD. Lastly, we discuss the association of cardiovascular risk factors and AD. We discuss both established cardiovascular risk factors and emerging putative risk factors, which exert their effect partly via CVD.

引用

页数：9

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