The evolution of non-reciprocal nuclear exchange in mushrooms as a consequence of genomic conflict

被引:23
作者
Aanen, DK
Kuyper, TW
Debets, AJM
Hoekstra, RF
机构
[1] Univ Copenhagen, Inst Biol, Dept Populat Ecol, DK-2100 Copenhagen, Denmark
[2] Univ Wageningen & Res Ctr, Dept Soil Qual, NL-6700 AA Wageningen, Netherlands
[3] Univ Wageningen & Res Ctr, Genet Lab, NL-6703 BD Wageningen, Netherlands
关键词
nucleo-mitochondrial conflict; mitochondrial inheritance; doubly uniparental inheritance; basidiomycetes; cytoplasmic male sterility;
D O I
10.1098/rspb.2004.2693
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Heterothallic mushrooms accomplish sex by exchanging nuclei without cytoplasm. Hyphal fusions occur between haploid mycelia resulting from germinated spores and subsequent reciprocal nuclear exchange without cytoplasmic mixing. The resulting dikaryon is therefore a cytoplasmic mosaic with uniformly distributed nuclei (two in each cell). Cytoplasmic inheritance is doubly uniparental: both mated monokaryons can potentially transmit their cytoplasm to the sexual spores, but normally only a single type per spore is found. Intracellular competition between mitochondria is thus limited, but at the dikaryon level, the two types of mitochondria compete over transmission. This creates the conditions for genomic conflict: within the dikaryon, a selfish mitochondrial mutant with increased relative transmission can be favoured, but selection between dikaryons will act against such a mitochondrial mutant. Moreover, because nuclear fitness is directly dependent on dikaryon fitness, a reduction in dikaryon fitness directly conflicts with nuclear interests. We propose that genomic conflict explains the frequent occurrence of non-reciprocal nuclear exchange in mushrooms. With non-reciprocal exchange, one monokaryon donates a nucleus and the other accepts it, but not vice versa as in the typical life cycle. We propose a model where non-reciprocal nuclear exchange is primarily driven by mitochondria inducing male sterility and the evolution of nuclear suppressors.
引用
收藏
页码:1235 / 1241
页数:7
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