Prognostic Significance of Periprocedural Versus Spontaneously Occurring Myocardial Infarction After Percutaneous Coronary Intervention in Patients With Acute Coronary Syndromes An Analysis From the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) Trial

被引：160

作者：

Prasad, Abhiram ^{[2
,3
]}

Gersh, Bernard J. ^{[2
,3
]}

Bertrand, Michel E. ^{[4
]}

Lincoff, A. Michael ^{[5
]}

Moses, Jeffrey W.

Ohman, E. Magnus ^{[6
]}

White, Harvey D. ^{[7
]}

Pocock, Stuart J. ^{[8
]}

McLaurin, Brent T. ^{[9
]}

Cox, David A. ^{[10
]}

Lansky, Alexandra J.

Mehran, Roxana

Stone, Gregg W. ^{[1
]}

机构：

[1] Columbia Univ, Cardiovasc Res Fdn, Med Ctr, New York, NY 10032 USA

[2] Mayo Clin & Mayo Fdn, Div Cardiovasc Dis, Rochester, MN 55905 USA

[3] Mayo Clin & Mayo Fdn, Dept Internal Med, Rochester, MN 55905 USA

[4] Hop Cardiol, F-59037 Lille, France

[5] Cleveland Clin, Cleveland, OH 44106 USA

[6] Duke Univ, Med Ctr, Durham, NC USA

[7] Auckland City Hosp, Green Lane Cardiovasc Serv, Auckland, New Zealand

[8] London Sch Hyg & Trop Med, London WC1, England

[9] Anderson Heart, Anderson, SC USA

[10] Mid Carolina Cardiol, Charlotte, NC USA

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2009年 / 54卷 / 05期

基金：

美国国家卫生研究院;

关键词：

angioplasty; myocardial infarction; prognosis; KINASE-MB ELEVATION; CARDIAC ENZYME ELEVATION; PRIMARY ANGIOPLASTY; EARLY REINFARCTION; ARTERY-DISEASE; TROPONIN-T; OUTCOMES; PATHOGENESIS; PREDICTORS; MECHANISMS;

D O I：

10.1016/j.jacc.2009.03.063

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives The aim of this study was to evaluate the relative impact of spontaneously occurring and periprocedural myocardial infarction (MI) on survival after percutaneous coronary intervention (PCI). Background The clinical significance of periprocedural MI after PCI remains uncertain. Methods Outcomes during a 1-year follow-up were evaluated among 7,773 patients enrolled in the ACUITY ( Acute Catheterization and Urgent Intervention Triage Strategy) trial with a non-ST-segment elevation acute coronary syndrome in whom PCI was performed. Results Periprocedural MI developed in 466 patients (6.0%), and spontaneous MI unrelated to PCI subsequently developed in 200 patients (2.6%). Patients developing spontaneous and periprocedural MI compared with those patients without MI had significantly greater unadjusted rates of mortality at 30 days (5.0% vs. 3.2% vs. 0.8%, respectively, p < 0.0001) and at 1 year (16.0% vs. 6.0% vs. 2.6%, respectively, p < 0.0001). In a time-updated multivariable analysis, after adjusting for differences in baseline and procedural characteristics between the groups, we found that spontaneous MI was a powerful independent predictor of subsequent mortality (hazard ratio: 7.49, 95% confidence interval: 4.95 to 11.33, p < 0.0001), whereas periprocedural MI was not a significant predictor of mortality (hazard ratio: 1.30, 95% confidence interval: 0.85 to 1.98, p = 0.22). Conclusions Among patients with acute coronary syndrome undergoing PCI, the spontaneous development of an MI unrelated to PCI is a powerful predictor of subsequent mortality. In contrast, periprocedural MI is a marker of baseline risk, atherosclerosis burden, and procedural complexity but in most cases does not have independent prognostic significance. (Comparison of Angiomax Versus Heparin in Acute Coronary Syndromes [ACS]; NCT00093158) (J Am Coll Cardiol 2009; 54: 477-86) (C) 2009 by the American College of Cardiology Foundation

引用

页码：477 / 486

页数：10

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