The outer mucus layer hosts a distinct intestinal microbial niche

被引：314

作者：

Li, Hai ^{[1
]}

Limenitakis, Julien P. ^{[1
]}

Fuhrer, Tobias ^{[2
]}

Geuking, Markus B. ^{[1
]}

Lawson, Melissa A. ^{[1
]}

Wyss, Madeleine ^{[1
]}

Brugiroux, Sandrine ^{[3
]}

Keller, Irene ^{[1
]}

Macpherson, Jamie A. ^{[1
]}

Rupp, Sandra ^{[1
]}

Stolp, Bettina ^{[4
]}

Stein, Jens V. ^{[4
]}

Stecher, Baerbel ^{[3
]}

Sauer, Uwe ^{[2
]}

McCoy, Kathy D. ^{[1
]}

Macpherson, Andrew J. ^{[1
]}

机构：

[1] Univ Bern, Univ Klin Viszerale Chirurg & Med, Inselspital, Maurice Muller Labs DKF, CH-3010 Bern, Switzerland

[2] Swiss Fed Inst Technol, Inst Mol Syst Biol, CH-8093 Zurich, Switzerland

[3] Max Von Pettenkofer Inst, German Ctr Infect Res DZIF, D-80336 Munich, Germany

[4] Univ Bern, Theodor Kocher Inst, CH-3012 Bern, Switzerland

来源：

NATURE COMMUNICATIONS | 2015年 / 6卷

基金：

欧洲研究理事会; 瑞士国家科学基金会;

关键词：

ESCHERICHIA-COLI; BACTEROIDES-THETAIOTAOMICRON; INTERACTION NETWORKS; HIGH-THROUGHPUT; GUT MICROBIOTA; E.-COLI; GROWTH; METABOLISM; BACTERIA; MUTANTS;

D O I：

10.1038/ncomms9292

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The overall composition of the mammalian intestinal microbiota varies between individuals: within each individual there are differences along the length of the intestinal tract related to host nutrition, intestinal motility and secretions. Mucus is a highly regenerative protective lubricant glycoprotein sheet secreted by host intestinal goblet cells; the inner mucus layer is nearly sterile. Here we show that the outer mucus of the large intestine forms a unique microbial niche with distinct communities, including bacteria without specialized mucolytic capability. Bacterial species present in the mucus show differential proliferation and resource utilization compared with the same species in the intestinal lumen, with high recovery of bioavailable iron and consumption of epithelial-derived carbon sources according to their genome-encoded metabolic repertoire. Functional competition for existence in this intimate layer is likely to be a major determinant of microbiota composition and microbial molecular exchange with the host.

引用

页数：13

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