High performance liquid chromatography of isoxazolyl-naphtho quinones: A comparison between experimental and theoretical lipophilicity

被引：2

作者：

Longhi, M

Linares, M

deBertorello, MM

机构：

[1] Departamento de Farmacia, Facultad de Ciencias Químicas, Univ. Nacional de Córdoba, 5016-Córdoba, Sucursal 16

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 1996年 / 19卷 / 12期

关键词：

D O I：

10.1080/10826079608014018

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

An RP-HPLC procedure was developed for determining the lipophilicity of a series of isoxazolyl-naphthoquinones which possess antibacterial, trypanosidal and antineoplasic activity. The experimental results were compared with theoretical log P values, and it was found that there was a good relationship between the two methods, except for very lipophilic compounds.

引用

页码：1947 / 1956

页数：10

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