The transcription factor PU.1 does not regulate lineage commitment but has lineage-specific effects

被引：22

作者：

McKercher, SR ^{[1
]}

Henkel, GW ^{[1
]}

Maki, RA ^{[1
]}

机构：

[1] Burnham Inst, La Jolla, CA 92037 USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 1999年 / 66卷 / 05期

关键词：

hematopoiesis; macrophage; myeloid; oncogene; spi-1;

D O I：

10.1002/jlb.66.5.727

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

PU.1 is a transcription factor shown to regulate the expression of many important genes in myeloid and B cells. At birth, mice homozygous for the disruption of the PU.1 gene have erythrocytes, megakaryocytes, and T cells, but no mature myeloid or B cells. Cells with an inability to develop to maturity were found in this mouse for B cells, neutrophils, eosinophils, mast cells, and monocytes. Rescue of early monocytic cells by transfection with the PU.1 gene results in renewed development to macrophages. These results demonstrate that PU.1 is an important regulator in the development of cells in the hematopoietic system.

引用

收藏

页码：727 / 732

页数：6

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