The United Kingdom Childhood Cancer Study of exposure to domestic sources of ionising radiation: I: radon gas

被引:69
作者
Cartwright, RA [1 ]
Law, G [1 ]
Roman, E [1 ]
Gurney, KA [1 ]
Gilman, E [1 ]
Eden, OB [1 ]
Mott, M [1 ]
Muir, K [1 ]
Goodhead, D [1 ]
Kendall, G [1 ]
Cheng, KK [1 ]
Day, N [1 ]
Cartwright, RA [1 ]
Craft, A [1 ]
Birch, JM [1 ]
Eden, OB [1 ]
McKinney, PA [1 ]
Peto, J [1 ]
Beral, V [1 ]
Roman, E [1 ]
Elwood, P [1 ]
Alexander, FE [1 ]
Chilvers, CED [1 ]
Doll, R [1 ]
Taylor, GM [1 ]
Greaves, M [1 ]
Goodhead, D [1 ]
Fry, FA [1 ]
Adams, G [1 ]
Cheng, KK [1 ]
Gilman, E [1 ]
Day, N [1 ]
Skinner, J [1 ]
Williams, D [1 ]
Cartwright, RA [1 ]
Craft, A [1 ]
Birch, JM [1 ]
Eden, OB [1 ]
McKinney, PA [1 ]
Deacon, J [1 ]
Peto, J [1 ]
Beral, V [1 ]
Roman, E [1 ]
Elwood, P [1 ]
Alexander, FE [1 ]
Mott, M [1 ]
Chilvers, CED [1 ]
Muir, K [1 ]
Cartwright, RA [1 ]
Law, G [1 ]
机构
[1] Univ Leeds, UKCCS, Inst Epidemiol, Leeds LS2 9LN, W Yorkshire, England
基金
英国医学研究理事会;
关键词
radon; childhood cancer risks; leukaemia; case-control;
D O I
10.1038/sj.bjc.6600276
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
This paper reports the results of the United Kingdom Childhood Cancer Study relating to risks associated with radon concentrations in participants homes at the time of diagnosis of cancer and for at least 6 months before. Results are given for 2226 case and 3773 control homes. No evidence to support an association between higher radon concentrations and risk of any of the childhood cancers was found. Indeed, evidence of decreasing cancer risks with increasing radon concentrations was observed. Adjustment for deprivation score for area of residence made little difference to this trend and similar patterns were evident in all regions and in all diagnostic groups. The study suggests that control houses had more features, such as double glazing and central heating, leading to higher radon levels than case houses. Further, case houses have features more likely to lead to lower radon levels, e.g. living-rooms above ground level, Consequently the case-control differences could have arisen because of differences between houses associated with deprivation that are not adequately allowed for by the deprivation score. (C) 2002 Cancer Research UK.
引用
收藏
页码:1721 / 1726
页数:6
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