LY354740 affects startle responding but not sensorimotor gating or discriminative effects of phencyclidine

被引：44

作者：

Schreiber, R

Lowe, D

Voerste, A

De Vry, J

机构：

[1] Bayer, CNS Res, D-42096 Wuppertal, Germany

[2] Bayer, Cent Res, D-51368 Leverkusen, Germany

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2000年 / 388卷 / 02期

关键词：

drug discrimination; gluramate receptor; metabotropic; schizophrenia;

D O I：

10.1016/S0014-2999(99)00844-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

LY354740 {(1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate monohydrate}, a selective group II metabotropic glutamate (mGlu) receptor agonist, was recently reported to attenuate the behavioral effects of phencyclidine (PCP) in rats. In the present study, LY354740 failed to attenuate the discriminative stimulus properties of PCP and its disruption of prepulse inhibition of the acoustic startle response, at a dose range which decreased startle responding. The suggestion that mGlu group II receptor activation induces antipsychotic effects may be premature. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：R3 / R4

页数：2

共 7 条

[1]

BAKSHI VP, 1994, J PHARMACOL EXP THER, V271, P787

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