Nonsteroidal anti-inflammatory drug and angiotensin converting enzyme inhibitor: A dangerous association in postoperative period.

被引：6

作者：

Badid, C ^{[1
]}

Chambrier, C ^{[1
]}

Aouifi, A ^{[1
]}

Boucaud, C ^{[1
]}

Bouletreau, P ^{[1
]}

机构：

[1] HOP HOTEL DIEU,HOSPICES CIVILS LYON,DEPT ANESTHESIE REANIMAT,F-69288 LYON 02,FRANCE

来源：

ANNALES FRANCAISES D ANESTHESIE ET DE REANIMATION | 1997年 / 16卷 / 01期

关键词：

nonsteroidal anti-inflammatory drug; angiotensin converting enzyme inhibitor; postoperative acute renal failure;

D O I：

10.1016/S0750-7658(97)84279-7

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

A 72-year-old man experienced a postoperative acute renal failure (ARF) from a nonsteroidal anti-inflammatory drug (NSAID) and an angiotensin converting enzyme inhibitor (ACEI) intake and promoted by an unrecognized myeloma, peroperative hypotension and hormonal response to surgical stress. This drug combination can result in ARF through a fail of glomerular filtration by combined renal blood flow changes: NSAID inhibit vasodilation by renal prostaglandins, and the vasoconstrictor effect on the efferent arteriole is inhibited by the ACEI. Nephrotoxicity during the simultaneous use of ACEI and NSAID is increased by other risk factors of renal insufficiency such as ageing, preexisting renal disease and hypovolaemia. In theses cases, a preventive therapy should be considered.

引用

页码：55 / 57

页数：3

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