TPA stimulation culture for improved detection of t(11;14)(q13;q32) in mantle cell lymphoma

被引：2

作者：

Barouk-Simonet, E

Andrieux, J

Copin, MC

Grardel-Duflos, N

Huyghe, P

Patte, JH

Preudhomme, C

Quesnel, B

Laï, JL ^{[1
]}

机构：

[1] CHRU Lille, Barre Nord Hop Jeanne Flandre, Med Genet Lab, F-59037 Lille, France

[2] CHRU Lille, Hop Calmette, Lab Anat Pathol, F-59000 Lille, France

[3] CHRU Lille, Hop Huriez, Serv Maladies Sang, F-59000 Lille, France

[4] CHRU Lille, Hop Calmette, Hematol Lab, F-59000 Lille, France

[5] Inst Rech Canc Lille, INSERM, U524, F-59045 Lille, France

来源：

ANNALES DE GENETIQUE | 2002年 / 45卷 / 03期

关键词：

mantle cell lymphoma; cytogenetics; translocation (11; 14)(q13; q32); TPA stimulated culture; improved detection;

D O I：

10.1016/S0003-3995(02)01122-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

Cytogenetic analysis of mantle cell lymphoma (MCL), characterized by the presence of t(11;14)(q13;q32) translocation, is often difficult because of the low proliferating rate of MCL cells and the presence of normal cells in bone marrow which may interfere with growth of MCL cells. We describe herein a TPA (12-O-tetradecanoylphorbol 13-acetate) stimulated culture to improve detection of t(11;14)(q13;q32) in 20 MCL patients regardless of the samples used. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：165 / 168

页数：4

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