Anti-Inflammatory Activity of Melatonin: a Focus on the Role of NLRP3 Inflammasome

被引：60

作者：

Ashrafizadeh, Milad ^{[1
,2
]}

Najafi, Masoud ^{[3
]}

Kavyiani, Nasim ^{[4
]}

Mohammadinejad, Reza ^{[5
]}

Farkhondeh, Tahereh ^{[6
,7
]}

Samarghandian, Saeed ^{[8
]}

机构：

[1] Sabanci Univ, Fac Engn & Nat Sci, Orta Mahalle,Univ Caddesi 27, TR-34956 Istanbul, Turkey

[2] Sabanci Univ Nanotechnol Res & Applicat Ctr SUNUM, TR-34956 Istanbul, Turkey

[3] Kermanshah Univ Med Sci, Sch Paramed Sci, Radiol & Nucl Med Dept, Kermanshah, Iran

[4] Univ Shushtar, Fac Vet Med Fac, Dept Basic Sci, Islamic Azad Branch, Shushtar, Khuzestan, Iran

[5] Kerman Univ Med Sci, Inst Neuropharmacol, Pharmaceut Res Ctr, Kerman, Iran

[6] Birjand Univ Med Sci, Med Toxicol & Drug Abuse Res Ctr, MTDRC, Birjand, Iran

[7] Birjand Univ Med Sci, Fac Pharm, Birjand, Iran

[8] Neyshabur Univ Med Sci, Noncommunicable Dis Res Ctr, Neyshabur, Iran

来源：

INFLAMMATION | 2021年 / 44卷 / 04期

关键词：

anti-inflammatory; disease therapy; inflammation; melatonin; NLRP3; EARLY BRAIN-INJURY; NUCLEUS PULPOSUS CELLS; ACUTE LUNG INJURY; OXIDATIVE STRESS; SPINAL-CORD; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; SUBARACHNOID HEMORRHAGE; AIRWAY INFLAMMATION; INTERVERTEBRAL DISC; CIGARETTE-SMOKING;

D O I：

10.1007/s10753-021-01428-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Melatonin is a hormone of the pineal gland that contributes to the regulation of physiological activities, such as sleep, circadian rhythm, and neuroendocrine processes. Melatonin is found in several plants and has pharmacological activities including antioxidant, anti-inflammatory, hepatoprotective, cardioprotective, and neuroprotective. It also has shown therapeutic efficacy in treatment of cancer and diabetes. Melatonin affects several molecular pathways to exert its protective effects. The NLRP3 inflammasome is considered a novel target of melatonin. This inflammasome contributes to enhanced level of IL-1 beta, caspase-1 activation, and pyroptosis stimulation. The function of NLRP3 inflammasome has been explored in various diseases, including cancer, diabetes, and neurological disorders. By inhibiting NLRP3, melatonin diminishes inflammation and influences various molecular pathways, such as SIRT1, microRNA, long non-coding RNA, and Wnt/beta-catenin. Here, we discuss these molecular pathways and suggest that melatonin-induced inhibition of NLRP3 should be advanced in disease therapy

引用

页码：1207 / 1222

页数：16

共 192 条

[1]

NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases [J].