Initial load of hepatitis B virus (HBV), its changing profile, and precore/core promoter mutations correlate with the severity and outcome of acute HBV infection

被引：70

作者：

Sainokami, Shigehiko

Abe, Koichi

Sato, Akihiro

Endo, Ryujin

Takikawa, Yasuhiro

Suzuki, Kazuyuki

Okamoto, Hiroaki

机构：

[1] First Department of Internal Medicine, Iwate Medical University, Iwate

[2] Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Tochigi

[3] Department of Internal Medicine, Fussa Hospital, Fussa, Tokyo 197-8511

来源：

JOURNAL OF GASTROENTEROLOGY | 2007年 / 42卷 / 03期

关键词：

fulminant hepatitis; serum HBV DNA level; precore/core promoter mutation;

D O I：

10.1007/s00535-006-1997-5

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

load in the early phase of acute HBV infection was associated with the severity of the disease. A high viral load on admission and the presence of both precore and core promoter mutations in patients with severe coagulopathy closely correlated with mortality.

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页码：241 / 249

页数：9

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