Serotonin transporter (5-HTTLPR) genotype, childhood abuse, and suicide attempts in adult psychiatric inpatients

被引:56
作者
Gibb, Brandon E. [1 ]
McGeary, John E.
Beevers, Christopher G.
Miller, Ivan W.
机构
[1] SUNY Binghamton, Dept Psychol, Binghamton, NY 13902 USA
[2] Brown Univ, Providence Vet Affairs Med Ctr, Providence, RI 02912 USA
[3] Brown Univ, Ctr Alcohol & Addict Studies, Providence, RI 02912 USA
[4] Brown Univ, Butler Hosp, Providence, RI 02912 USA
[5] Univ Texas, Austin, TX 78712 USA
关键词
D O I
10.1521/suli.2006.36.6.687
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
There is growing evidence that a functional polymorphism in the serotonin transporter gene (5-HTTLPR) moderates the impact of negative life events (e.g., childhood abuse) on the development of depression. However, it is unclear whether the gene x environment interaction predicts suicide attempts specifically. In addition, previous studies have not examined different forms of childhood abuse separately. In the current study, we found that 5-HTTLPR genotype moderated the link between childhood physical and sexual, but not emotional, abuse and adult psychiatric inpatients' histories of suicide attempts.
引用
收藏
页码:687 / 693
页数:7
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