The 5′-untranslated region of Parkinson's disease α-synuclein messengerRNA contains a predicted iron responsive element

被引:142
作者
Friedlich, A. L. [1 ]
Tanzi, R. E.
Rogers, J. T.
机构
[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Neurochem Lab, Charlestown, MA USA
[2] Harvard Univ, Sch Med, Genet & Aging Res Unit, MassGen Inst Neurodegenerat Dis,Massachusetts Gen, Charlestown, MA USA
[3] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Psychiat, Charlestown, MA USA
[4] Harvard Univ, Sch Med, VA Healthcare Syst, Dept Psychiat, Brockton, MA USA
[5] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA USA
关键词
D O I
10.1038/sj.mp.4001937
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:222 / 223
页数:2
相关论文
共 9 条
[1]   Neuropathological spectrum of synucleinopathies [J].
Jellinger, KA .
MOVEMENT DISORDERS, 2003, 18 :S2-S12
[2]   Mechanisms of Parkinson's disease linked to pathological α-synuclein:: New targets for drug discovery [J].
Lee, Virginia M. -Y. ;
Trojanowski, John Q. .
NEURON, 2006, 52 (01) :33-38
[3]  
MAROTEAUX L, 1988, J NEUROSCI, V8, P2804
[4]   Mutation in the alpha-synuclein gene identified in families with Parkinson's disease [J].
Polymeropoulos, MH ;
Lavedan, C ;
Leroy, E ;
Ide, SE ;
Dehejia, A ;
Dutra, A ;
Pike, B ;
Root, H ;
Rubenstein, J ;
Boyer, R ;
Stenroos, ES ;
Chandrasekharappa, S ;
Athanassiadou, A ;
Papapetropoulos, T ;
Johnson, WG ;
Lazzarini, AM ;
Duvoisin, RC ;
DiIorio, G ;
Golbe, LI ;
Nussbaum, RL .
SCIENCE, 1997, 276 (5321) :2045-2047
[5]   An iron-responsive element type II in the 5′-untranslated region of the Alzheimer's amyloid precursor protein transcript [J].
Rogers, JT ;
Randall, JD ;
Cahill, CM ;
Eder, PS ;
Huang, XD ;
Gunshin, H ;
Leiter, L ;
McPhee, J ;
Sarang, SS ;
Utsuki, T ;
Greig, NH ;
Lahiri, DK ;
Tanzi, RE ;
Bush, AI ;
Giordano, T ;
Gullans, SR .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (47) :45518-45528
[6]   α-synuclein locus triplication causes Parkinson's disease [J].
Singleton, AB ;
Farrer, M ;
Johnson, J ;
Singleton, A ;
Hague, S ;
Kachergus, J ;
Hulihan, M ;
Peuralinna, T ;
Dutra, A ;
Nussbaum, R ;
Lincoln, S ;
Crawley, A ;
Hanson, M ;
Maraganore, D ;
Adler, C ;
Cookson, MR ;
Muenter, M ;
Baptista, M ;
Miller, D ;
Blancato, J ;
Hardy, J ;
Gwinn-Hardy, K .
SCIENCE, 2003, 302 (5646) :841-841
[7]   MOLECULAR-CLONING OF CDNA-ENCODING AN UNRECOGNIZED COMPONENT OF AMYLOID IN ALZHEIMER-DISEASE [J].
UEDA, K ;
FUKUSHIMA, H ;
MASLIAH, E ;
XIA, Y ;
IWAI, A ;
YOSHIMOTO, M ;
OTERO, DAC ;
KONDO, J ;
IHARA, Y ;
SAITOH, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (23) :11282-11286
[8]   Iron, brain ageing and neurodegenerative disorders [J].
Zecca, L ;
Youdim, MBH ;
Riederer, P ;
Connor, JR ;
Crichton, RR .
NATURE REVIEWS NEUROSCIENCE, 2004, 5 (11) :863-873
[9]   ON FINDING ALL SUBOPTIMAL FOLDINGS OF AN RNA MOLECULE [J].
ZUKER, M .
SCIENCE, 1989, 244 (4900) :48-52