Localization of premotoneurons for an NMDA-induced repetitive rhythmical activity to TMNs

被引：17

作者：

Enomoto, A ^{[1
]}

Kogo, M ^{[1
]}

Koizumi, H ^{[1
]}

Ishihama, K ^{[1
]}

Yamanishi, T ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Dent, Dept Oral & Maxillofacial Surg, Suita, Osaka 5650871, Japan

来源：

NEUROREPORT | 2002年 / 13卷 / 17期

关键词：

brain stem; fragmented slice preparation; jaw movement; rhythmical activity; trigeminal system;

D O I：

10.1097/00001756-200212030-00027

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The localization or characteristics of the premotoneurons for trigeminal rhythmical activity have not been clarified. We investigated the localization of premotoneurons generating an NMDA-induced repetitive rhythmical activity to trigeminal motoneurons (TMNs). The minimal circuitry for this rhythmical activity was determined using a fragmented slice preparation of the isolated brain stem from neonatal rats (0-3 days old). We recorded rhythmical neural activities from TMNs using whole and fragmented brain stem slices preparation including the trigeminal motor nucleus in the presence of the excitatory amino acid agonist NMA and the GABAA receptor antagonist, bicuculline methiodide (BIC). TMNs receive projections from premotoneurons for an NMDA-induced rhythmical activity, which can be located in the area 300 mum surrounding the trigeminal motor nucleus. NMA (20 muM) and BIC (10 muM) induced repetitive rhythmical activities on TMNs.

引用

页码：2303 / 2307

页数：5

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