Chromosomal localization of the adrenoleukodystrophy-related gene in man and mice

被引：14

作者：

Savary, S

TrofferCharlier, N

Gyapay, G

Mattei, MG

Chimini, G

机构：

[1] CNRS MARSEILLE LUMINY,INSERM,CTR IMMUNOL,F-13288 MARSEILLE 9,FRANCE

[2] IGBMC,INSERM,CNRS,ILLKIRCH GRAFFENS,FRANCE

[3] CNRS,URA 1922 GENETHON,EVRY,FRANCE

[4] INSERM,F-13258 MARSEILLE,FRANCE

来源：

EUROPEAN JOURNAL OF HUMAN GENETICS | 1997年 / 5卷 / 02期

关键词：

ATP binding cassette transporters; adrenoleukodystrophy; in situ mapping; PMP70;

D O I：

10.1159/000484741

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report here on the chromosomal mapping of the adrenoleukodystrophy-related (ALDR) gene on both the human and the mouse genomes. This gene encodes a peroxisomal ATP binding cassette transporter, closely related to the transporter identified as responsible for the adrenoleukodystrophy phenotype. ALDR maps on the syntenic region on murine and human autosomes. In addition, we could determine its position in relation to known microsatellite framework markers; this will allow to test its role in Zellweger syndrome and/or related peroxisomal disorders.

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页码：99 / 101

页数：3

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