Some Pharmacological Properties of Neural KCNQ Channels

被引：6

作者：

Brown, D. A. ^{[1
]}

Selyanko, A. A. ^{[1
]}

Hadley, J. K. ^{[1
]}

Tatulian, L. ^{[1
]}

机构：

[1] UCL, London, England

来源：

NEUROPHYSIOLOGY | 2002年 / 34卷 / 2-3期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

neural KCNQ channels; neuronal excitability; linopirdine; TEA; retigabine;

D O I：

10.1023/A:1020768914645

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The lecture summarizes data on the structural and pharmacological properties of KCNQ channels, in particular KCNQ2-5, associated primarily with the nervous system. The KCNQ channels are known to play a crucial role in the control of neuronal excitability. Two classes of drugs altering KCNQ channel activity and therefore producing considerable changes in neuronal excitability are described. These are KCNQ/M channel blocking agents (linopirdine, TEA) and KCNQ channel enhancers (retigabine).

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收藏

页码：91 / 94

页数：4

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