Polymerase chain reaction detection of Chlamydia pneumoniae in circulating white blood cells

被引：36

作者：

Boman, J

Gaydos, CA

机构：

[1] Umea Univ, Dept Virol, Umea, Sweden

[2] Johns Hopkins Univ, Sch Med, Div Infect Dis, Baltimore, MD 21205 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2000年 / 181卷

关键词：

D O I：

10.1086/315609

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Several recently published studies suggest that Chlamydia pneumoniae may represent a risk factor for atherosclerosis or its complications. In order to establish whether C. pneumoniae is causally linked to atherosclerotic diseases, clinical intervention trials may be needed. However, to identify eligible subjects with a persistent C. pneumoniae infection and to monitor the effect of antibiotic therapy, there is a need for a reliable diagnostic marker. Blood-based polymerase chain reaction assays may be of value for identifying patients persistently infected with C. pneumoniae and for assessing the microbiologic efficacy of antichlamydial therapy in clinical intervention trials.

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收藏

页码：S452 / S454

页数：3

相关论文

共 23 条

[1] Chlamydia pneumoniae DNA detection in peripheral blood mononuclear cells is predictive of vascular infection [J].

Blasi, F ;

Boman, J ;

Esposito, G ;

Melissano, G ;

Chiesa, R ;

Cosentini, R ;

Tarsia, P ;

Tshomba, Y ;

Betti, M ;

Alessi, M ;

Morelli, N ;

Allegra, L .

JOURNAL OF INFECTIOUS DISEASES, 1999, 180 (06) :2074-2076

[2] High prevalence of Chlamydia pneumoniae DNA in peripheral blood mononuclear cells in patients with cardiovascular disease and in middle-aged blood donors [J].

Boman, J ;

Söderberg, S ;

Forsberg, J ;

Birgander, LS ;

Allard, A ;

Persson, K ;

Jidell, E ;

Kumlin, U ;

Juto, P ;

Waldenström, A ;

Wadell, G .

JOURNAL OF INFECTIOUS DISEASES, 1998, 178 (01) :274-277

[3] Rapid diagnosis of respiratory Chlamydia pneumoniae infection by nested touchdown polymerase chain reaction compared with culture and antigen detection by EIA [J].

Boman, J ;

Allard, A ;

Persson, K ;

Lundborg, M ;

Juto, P ;

Wadell, G .

JOURNAL OF INFECTIOUS DISEASES, 1997, 175 (06) :1523-1526

[4] Peripheral-blood-based PCR assay to identify patients with active pulmonary tuberculosis [J].

Condos, R ;

McClune, A ;

Rom, WN ;

Schluger, NW .

LANCET, 1996, 347 (9008) :1082-1085

[5] LP(A) LIPOPROTEIN, IGG, IGA AND IGM ANTIBODIES TO CHLAMYDIA-PNEUMONIAE AND HLA CLASS-II GENOTYPE IN EARLY CORONARY-ARTERY DISEASE [J].

DAHLEN, GH ;

BOMAN, J ;

BIRGANDER, LS ;

LINDBLOM, B .

ATHEROSCLEROSIS, 1995, 114 (02) :165-174

[6] Chronic infections and coronary heart disease: is there a link? [J].

Danesh, J ;

Collins, R ;

Peto, R .

LANCET, 1997, 350 (9075) :430-436

[7] In vitro susceptibilities of Chlamydia pneumoniae isolates from German patients and synergistic activity of antibiotic combinations [J].

Freidank, HM ;

Losch, P ;

Vögele, H ;

Wiedmann-Al-Ahmad, M .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (07) :1808-1810

[8] Replication of Chlamydia pneumoniae in vitro in human macrophages, endothelial cells, and aortic artery smooth muscle cells [J].

Gaydos, CA ;

Summersgill, JT ;

Sahney, NN ;

Ramirez, JA ;

Quinn, TC .

INFECTION AND IMMUNITY, 1996, 64 (05) :1614-1620

[9] Viability and gene expression in Chlamydia trachomatis during persistent infection of cultured human monocytes [J].

Gerard, HC ;

Kohler, L ;

Branigan, PJ ;

Zeidler, H ;

Schumacher, HR ;

Hudson, AP .

MEDICAL MICROBIOLOGY AND IMMUNOLOGY, 1998, 187 (02) :115-120

[10] CHLAMYDIA-PNEUMONIAE (TWAR) IN ATHEROSCLEROSIS OF THE CAROTID-ARTERY [J].

GRAYSTON, JT ;

KUO, CC ;

COULSON, AS ;

CAMPBELL, LA ;

LAWRENCE, RD ;

LEE, MJ ;

STRANDNESS, ED ;

WANG, SP .

CIRCULATION, 1995, 92 (12) :3397-3400