Hyaluronan: From extracellular glue to pericellular cue

被引：1707

作者：

Toole, BP ^{[1
]}

机构：

[1] Med Univ S Carolina, Dept Anat & Cell Biol, Charleston, SC 29425 USA

来源：

NATURE REVIEWS CANCER | 2004年 / 4卷 / 07期

关键词：

D O I：

10.1038/nrc1391

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hyaluronan is an extracellular and cell-surface-associated polysaccharide that is traditionally regarded as a biological 'goo' that participates in lubricating joints or holding together gel-like connective tissues. Although these are common physiological roles of hyaluronan in adult organisms, hyaluronan also functions as a microenvironmental cue that co-regulates cell behaviour during embryonic development, healing processes, inflammation and tumour development. Recent work highlights a key role for interactions between hyaluronan and tumour cells in several aspects of malignancy and indicates the possibility of new therapeutic strategies.

引用

页码：528 / 539

页数：12

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