Farnesoid X receptor immunolocalization in reproductive tissues of adult female rabbits

被引：12

作者：

Anaya-Hernandez, Arely ^{[1
]}

Mendez-Tepepa, Maribel ^{[2
]}

Hernandez-Aragon, Laura G. ^{[2
]}

Pacheco, Pablo ^{[3
]}

Martinez-Gomez, Margarita ^{[3
,4
]}

Castelan, Francisco ^{[4
]}

Cuevas, Estela ^{[4
]}

机构：

[1] Univ Veracruzana, Xalapa 91000, Veracruz, Mexico

[2] Univ Autonoma Tlaxcala, Tlaxcala 90062, Mexico

[3] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City 04510, DF, Mexico

[4] Univ Autonoma Tlaxcala, Ctr Tlaxcala Biol Conducta, Tlaxcala 90062, Mexico

来源：

ACTA HISTOCHEMICA | 2014年 / 116卷 / 06期

关键词：

Ovary; Oviduct; Uterus; Vagina; Oviductal crypts; Reproduction; Rabbit; NUCLEAR RECEPTOR; BREAST-CANCER; EXPRESSION; FXR; PREGNANCY; OVIDUCT; CELLS; IDENTIFICATION; TRANSPORT; AGONISTS;

D O I：

10.1016/j.acthis.2014.05.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Farnesoid X receptor (FXR) has been involved in lipid metabolism, cell proliferation, apoptosis, and aromatase expression, as well as in the steroid synthesis and signaling. Considering that these events occur in reproductive tissues in females, the aim of the present study was to determine the immunolocalization of FXR in the ovary, oviduct, uterus, and vagina of rabbits. Rabbits were sacrificed and their reproductive tissues were excised and histologically processed. Immunohistochemistry for FXR was done and reproductive tissues were photographed. FXR immunoreactivity was found in all types of ovarian follicles, ovarian stroma, and corpus luteum of virgin and pregnant rabbits. Also, oviductal and vaginal epithelium of virgins, as well as the oviductal smooth muscle, showed anti-FXR immunoreactivity. The uterine epithelium and musculature of virgins had scarce anti-FXR immunoreactivity. Although the role of FXR in female reproductive tissues is still not known, it is possible to consider various functions related to the reproductive tissue. (C) 2014 Elsevier GmbH. All rights reserved.

引用

页码：1068 / 1074

页数：7

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