Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neurons

被引：113

作者：

Davidson, Steve ^{[1
,2
]}

Zhang, Xijing ^{[2
]}

Khasabov, Sergey G. ^{[3
]}

Simone, Donald A. ^{[1
,3
]}

Giesler, Glenn J., Jr. ^{[1
,2
]}

机构：

[1] Univ Minnesota, Grad Program Neurosci, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Neurosci, Minneapolis, MN USA

[3] Univ Minnesota, Dept Diagnost & Biol Sci, Minneapolis, MN USA

来源：

NATURE NEUROSCIENCE | 2009年 / 12卷 / 05期

基金：

美国国家卫生研究院;

关键词：

HISTAMINE; RESPONSES; STIMULI;

D O I：

10.1038/nn.2292

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Itch is relieved by scratching, but the neural mechanisms that are responsible for this are unknown. Spinothalamic tract (STT) neurons respond to itch-producing agents and transmit pruritic information to the brain. We observed that scratching the cutaneous receptive field of primate STT neurons produced inhibition during histamine-evoked activity but not during spontaneous activity or activity evoked by a painful stimulus, suggesting that scratching inhibits the transmission of itch in the spinal cord in a state-dependent manner.

引用

收藏

页码：544 / 546

页数：3

相关论文

共 14 条

[1] Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch [J].

Andrew, D ;

Craig, AD .

NATURE NEUROSCIENCE, 2001, 4 (01) :72-77

[2]

Brull SJ, 1999, SOMATOSENS MOT RES, V16, P299

[3] Responses of rat spinal dorsal horn neurons to intracutaneous microinjection of histamine, capsaicin, and other irritants [J].

Carstens, E .

JOURNAL OF NEUROPHYSIOLOGY, 1997, 77 (05) :2499-2514

[4] The itch-producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons [J].

Davidson, Steve ;

Zhang, Xijing ;

Yoon, Chul H. ;

Khasabov, Sergey G. ;

Simone, Donald A. ;

Giesler, Glenn J., Jr. .

JOURNAL OF NEUROSCIENCE, 2007, 27 (37) :10007-10014

[5] NEURAL MECHANISMS INVOLVED IN ITCH, ITCHY SKIN, AND TICKLE SENSATIONS [J].

GRAHAM, DT ;

GOODELL, H ;

WOLFF, HG .

JOURNAL OF CLINICAL INVESTIGATION, 1951, 30 (01) :37-49

[6] The neurobiology of itch [J].

Ikoma, Akihiko ;

Steinhoff, Martin ;

Staender, Sonja ;

Yosipovitch, Gil ;

Schmelz, Martin .

NATURE REVIEWS NEUROSCIENCE, 2006, 7 (07) :535-547

[7] A role for polymodal C-fiber afferents in nonhistaminergic itch [J].

Johanek, Lisa M. ;

Meyer, Richard A. ;

Friedman, Robert M. ;

Greenquist, Kenneth W. ;

Shim, Beom ;

Borzan, Jasenka ;

Hartke, Tim ;

LaMotte, Robert H. ;

Ringkamp, Matthias .

JOURNAL OF NEUROSCIENCE, 2008, 28 (30) :7659-7669

[8] Imaging of central itch modulation in the human brain using positron emission tomography [J].

Mochizuki, H ;

Tashiro, M ;

Kano, M ;

Sakurada, Y ;

Itoh, M ;

Yanai, K .

PAIN, 2003, 105 (1-2) :339-346

[9] Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens [J].

Schmelz, M ;

Schmidt, R ;

Weidner, C ;

Hilliges, M ;

Torebjörk, HE ;

Handwerker, HO .

JOURNAL OF NEUROPHYSIOLOGY, 2003, 89 (05) :2441-2448

[10] TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase [J].

Shim, Won-Sik ;

Tak, Min-Ho ;

Lee, Mi-Hyun ;

Kim, Minjung ;

Kim, Minkyung ;

Koo, Jae-Yeon ;

Lee, Chang-Hun ;

Kim, Misook ;

Oh, Uhtaek .

JOURNAL OF NEUROSCIENCE, 2007, 27 (09) :2331-2337