Positron emission tomography imaging of cell proliferation in oncology

被引：24

作者：

Kenny, LM

Aboagye, EO

Price, PM

机构：

[1] Univ Manchester, Acad Dept Radiat Oncol, Wolfson Mol Imaging Ctr, Manchester, Lancs, England

[2] Hammersmith Hosp, Mol Therapy Grp, London, England

[3] Hammersmith Hosp, PET Oncol Grp, London, England

来源：

CLINICAL ONCOLOGY | 2004年 / 16卷 / 03期

关键词：

Cell cycle; FLT; FDG; imaging of cell proliferation; PET scanning; tumour; thymidine;

D O I：

10.1016/j.clon.2003.10.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumour-cell proliferation is a hallmark of the malignant phenotype. Positron emission tomography (PET) offers a unique method of imaging biological and biochemical changes in vivo. Radiolabelled thymidine and thymidine analogues are currently in development as PET tracers. By studying the uptake and kinetics of such compounds using PET, a measure of DNA synthesis and hence cell proliferation can be obtained. Molecular imaging of cellular proliferation with PET is now possible, and has the potential to play an important role in the evaluation of efficacy of new anti-cancer agents. (C) 2004 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

引用

页码：176 / 185

页数：10

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