机构:
Childrens Hosp, Dept Surg, Boston, MA 02115 USAChildrens Hosp, Dept Surg, Boston, MA 02115 USA
Klagsbrun, M
[1
]
Moses, MA
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机构:Childrens Hosp, Dept Surg, Boston, MA 02115 USA
Moses, MA
机构:
[1] Childrens Hosp, Dept Surg, Boston, MA 02115 USA
[2] Childrens Hosp, Dept Pathol, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Boston, MA 02115 USA
来源:
CHEMISTRY & BIOLOGY
|
1999年
/
6卷
/
08期
关键词:
D O I:
10.1016/S1074-5521(99)80081-7
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
New insights into the mechanisms by which blood vessels develop (angiogenesis) have been gained recently, primarily by the identification of factors that inhibit and promote this process. Angiogenesis-stimulating factors are being used to promote growth of new blood vessels in ischemic disease. In contrast, anti-angiogenesis factors are being used as inhibitors of neovascularization to control tumor growth and metastasis.