Noninvasive ventilation in critically ill patients with the Middle East respiratory syndrome

被引：75

作者：

Alraddadi, Basem M. ^{[1
,2
]}

Qushmaq, Ismael ^{[1
]}

Al-Hameed, Fahad M. ^{[3
]}

Mandourah, Yasser ^{[4
]}

Almekhlafi, Ghaleb A. ^{[4
]}

Jose, Jesna ^{[5
]}

Al-Omari, Awad ^{[6
]}

Kharaba, Ayman ^{[7
]}

Almotairi, Abdullah ^{[8
]}

Al Khatib, Kasim ^{[9
]}

Shalhoub, Sarah ^{[10
,11
]}

Abdulmomen, Ahmed ^{[12
]}

Mady, Ahmed ^{[13
,14
]}

Solaiman, Othman ^{[15
]}

Al-Aithan, Abdulsalam M. ^{[16
]}

Al-Raddadi, Rajaa ^{[17
]}

Ragab, Ahmed ^{[18
]}

Balkhy, Hanan H. ^{[19
]}

Al Harthy, Abdulrahman ^{[14
]}

Sadat, Musharaf ^{[20
]}

Tlayjeh, Haytham ^{[20
]}

Merson, Laura ^{[21
]}

Hayden, Frederick G. ^{[22
]}

Fowler, Robert A. ^{[23
,24
]}

Arabi, Yaseen M. ^{[20
]}

机构：

[1] King Faisal Specialist Hosp & Res Ctr, Dept Med, Jeddah, Saudi Arabia

[2] Univ Jeddah, Dept Med, Jeddah, Saudi Arabia

[3] King Saud bin Abdulaziz Univ Hlth Sci, King Abdullah Int Med Res Ctr, King Abdulaziz Med City, Dept Intens Care,Coll Med, Jeddah, Saudi Arabia

[4] Minist Def, Prince Sultan Mil Med City, Mil Med Serv, Riyadh, Saudi Arabia

[5] King Saud bin Abdulaziz Univ Hlth Sci, Dept Biostat & Bioinformat, King Abdullah Int Med Res Ctr, Coll Med, Riyadh, Saudi Arabia

[6] Alfaisal Univ, Dept Intens Care, Dr Sulaiman Al Habib Grp Hosp, Coll Med, Riyadh, Saudi Arabia

[7] King Fahad Hosp, Ohoud Hosp, Dept Crit Care, Al Madinah Al Monawarah, Saudi Arabia

[8] King Fahad Med City, Crit Care Med, Riyadh, Saudi Arabia

[9] Al Noor Specialist Hosp, Dept Intens Care, Mecca, Saudi Arabia

[10] Univ Western Ontario, Div Infect Dis, Dept Med, London, ON, Canada

[11] King Fahad Armed Forces Hosp, Div Infect Dis, Dept Med, Jeddah, Saudi Arabia

[12] King Saud Univ, Riyadh, Saudi Arabia

[13] Tanta Univ Hosp, Intens Care, Dept Anesthesiol, Tanta, Egypt

[14] King Saud Med City, Dept Intens Care, Riyadh, Saudi Arabia

[15] King Faisal Specialist Hosp & Res Ctr, Riyadh, Saudi Arabia

[16] King Abdulaziz Hosp, Dept Intens Care, Al Hasa, Saudi Arabia

[17] Minist Hlth, King Abdulaziz Univ Hosp, Dept Family & Community Med, Jeddah, Saudi Arabia

[18] King Fahad Cent Hosp, Dept Intens Care, Jeddah, Saudi Arabia

[19] King Saud bin Abdulaziz Univ Hlth Sci, King Abdullah Int Med Res Ctr, Infect Prevent & Control Dept, Coll Med,King Abdulaziz Med City, Riyadh, Saudi Arabia

[20] King Saud bin Abdulaziz Univ Hlth Sci, King Abdullah Int Med Res Ctr, Dept Intens Care, Coll Med,King Abdulaziz Med City, Riyadh, Saudi Arabia

[21] Univ Oxford, Infect Dis Data Observ, Churchill Hosp, Int Severe Acute Resp & Emerging Infect Consortiu, Headington, England

[22] Univ Virginia, Sch Med, Dept Med, Div Infect Dis & Int Hlth,Int Severe Acute Resp &, Charlottesville, VA 22908 USA

[23] Univ Toronto, Dept Crit Care Med, Sunnybrook Hosp, Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada

[24] Univ Toronto, Dept Med, Sunnybrook Hosp, Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada

来源：

INFLUENZA AND OTHER RESPIRATORY VIRUSES | 2019年 / 13卷 / 04期

关键词：

acute respiratory distress syndrome; coronavirus; Middle East respiratory syndrome; noninvasive ventilation; pneumonia; Saudi Arabia; severe acute respiratory infection; POSITIVE-PRESSURE VENTILATION; ACUTE LUNG INJURY; CORONAVIRUS; FAILURE; INFECTION; PNEUMONIA; OUTBREAK; OUTCOMES;

D O I：

10.1111/irv.12635

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

Background Noninvasive ventilation (NIV) has been used in patients with the Middle East respiratory syndrome (MERS) with acute hypoxemic respiratory failure, but the effectiveness of this approach has not been studied. Methods Patients with MERS from 14 Saudi Arabian centers were included in this analysis. Patients who were initially managed with NIV were compared to patients who were managed only with invasive mechanical ventilation (invasive MV). Results Of 302 MERS critically ill patients, NIV was used initially in 105 (35%) patients, whereas 197 (65%) patients were only managed with invasive MV. Patients who were managed with NIV initially had lower baseline SOFA score and less extensive infiltrates on chest radiograph compared with patients managed with invasive MV. The vast majority (92.4%) of patients who were managed initially with NIV required intubation and invasive mechanical ventilation, and were more likely to require inhaled nitric oxide compared to those who were managed initially with invasive MV. ICU and hospital length of stay were similar between NIV patients and invasive MV patients. The use of NIV was not independently associated with 90-day mortality (propensity score-adjusted odds ratio 0.61, 95% CI [0.23, 1.60] P = 0.27). Conclusions In patients with MERS and acute hypoxemic respiratory failure, NIV failure was very high. The use of NIV was not associated with improved outcomes.

引用

页码：382 / 390

页数：9

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