3DCoffee@igs: a web server for combining sequences and structures into a multiple sequence alignment

被引：132

作者：

Poirot, O

Suhre, K

Abergel, C

O'Toole, E

Notredame, C

机构：

[1] CNRS, UPR 2589, F-13402 Marseille 20, France

[2] Univ Lausanne, Swiss Inst Bioinformat, CH-1066 Epalinges, Switzerland

[3] Hewlett Packard Corp, HP High Performance Tech Comp Div, Galway, Ireland

来源：

NUCLEIC ACIDS RESEARCH | 2004年 / 32卷

关键词：

D O I：

10.1093/nar/gkh382

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper presents 3DCoffee@igs, a web-based tool dedicated to the computation of high-quality multiple sequence alignments (MSAs). 3D-Coffee makes it possible to mix protein sequences and structures in order to increase the accuracy of the alignments. Structures can be either provided as PDB identifiers or directly uploaded into the server. Given a set of sequences and structures, pairs of structures are aligned with SAP while sequence-structure pairs are aligned with Fugue. The resulting collection of pairwise alignments is then combined into an MSA with the T-Coffee algorithm. The server and its documentation are available from http://igs-server.cnrs-mrs.fr/Tcoffee/.

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页码：W37 / W40

页数：4

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