CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis

被引:88
作者
Kolle, G
Georgas, K
Holmes, GP
Little, MH [1 ]
Yamada, T
机构
[1] Univ Queensland, Ctr Mol & Cellular Biol, Brisbane, Qld 4072, Australia
[2] Univ Queensland, Dept Biochem, Brisbane, Qld 4072, Australia
[3] Mem Sloan Kettering Canc Ctr, Program Mol Biol, Howard Hughes Med Inst, New York, NY 10021 USA
基金
英国医学研究理事会;
关键词
cysteine-rich repeat; insulin-like growth factor binding protein; notochord; floor plate; motor neuron; spinal cord; brain; CNS development; organogenesis; chordin; short gastrulation; bone morphogenic protein; transforming growth factor-beta; holoprosencephaly; 2; spastic paraplegia type 4; hereditary essential tremor 2; human; mouse; C; elegans;
D O I
10.1016/S0925-4773(99)00248-8
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Development of the vertebrate central nervous system is thought to be controlled by intricate cell-cell interactions and spatio-temporally regulated gene expressions. The details of these processes are still not fully understood. We have isolated a novel vertebrate gene, CRIM1/Crim1 in human and mouse. Human CRIM1 maps to chromosome 2p21 close to the Spastic Paraplegia 4 locus, Crim1 is expressed in the notochord, somites, floor plate, early motor neurons and interneuron subpopulations within the developing spinal cord. CRIM1 appears to be evolutionarily conserved and encodes a putative transmembrane protein containing an IGF-binding protein motif and multiple cysteine-rich repeats similar to those in the BMP-associating chordin and sog proteins, Our results suggest a role for CRIM1/Crim1 in CNS development possibly via growth factor binding. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:181 / 193
页数:13
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