Clinical isolates of Staphylococcus aureus with ribosomal mutations conferring resistance to macrolides

被引：68

作者：

Prunier, AL

Malbruny, B

Tandé, D

Picard, B

Leclercq, R

机构：

[1] CHU Morvan, Microbiol Serv, Brest, France

[2] CHU Cote Nacre, Microbiol Serv, Caen, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 09期

关键词：

D O I：

10.1128/AAC.46.9.3054-3056.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Six strains of Staphylococcus aureus isolated from cystic fibrosis patients after treatment with azithromycin were cross-resistant to azithromycin and erythromycin. None of the isolates contained erm or msr(A) genes, but they all carried either A2058G/U or A2059G mutations within the rrl genes, with a majority of the rRNA copies bearing the mutation. One strain displayed an additional mutation in the rplV gene, encoding the L22 ribosomal protein.

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页码：3054 / 3056

页数：3

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