Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors

被引：459

作者：

Shaked, Yuval

Ciarrocchi, Alessia

Franco, Marcela

Lee, Christina R.

Man, Shan

Cheung, Alison M.

Hicklin, Daniel J.

Chaplin, David

Foster, F. Stuart

Benezra, Robert

Kerbel, Robert S. ^{[1
]}

机构：

[1] Sunnybrook Hlth Sci Ctr, Dept Mol & Cellular Biol Res, Toronto, ON M4N 3M5, Canada

[2] Mem Sloan Kettering Canc Ctr, Program Canc Biol & Genet, New York, NY 10021 USA

[3] Sunnybrook Hlth Sci Ctr, Dept Imaging Res, Toronto, ON M4N 3M5, Canada

[4] ImClone Syst, New York, NY 10014 USA

[5] OXiGENE Inc, Waltham, MA 02451 USA

来源：

SCIENCE | 2006年 / 313卷 / 5794期

关键词：

D O I：

10.1126/science.1127592

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The contribution of bone marrow-derived circulating endothelial progenitor cells (CEPs) to tumor angiogenesis has been controversial, primarily because of their low numbers in blood vessels of untreated tumors. We show that treatment of tumor-bearing mice with vascular disrupting agents (VDAs) leads to an acute mobilization of CEPs, which home to the viable tumor rim that characteristically remains after such therapy. Disruption of this CEP spike by antiangiogenic drugs or by genetic manipulation resulted in marked reductions in tumor rim size and blood flow as well as enhanced VDA antitumor activity. These findings also provide a mechanistic rationale for the enhanced efficacy of VDAs when combined with antiangiogenic drugs.

引用

页码：1785 / 1787

页数：3

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