Haemoglobin adducts as biomarkers of exposure to the herbicides propanil and fluometuron

被引：6

作者：

McClure, GYH ^{[1
]}

Freeman, JP ^{[1
]}

Lay, JO ^{[1
]}

Hinson, JA ^{[1
]}

机构：

[1] NATL CTR TOXICOL RES,DIV CHEM,JEFFERSON,AR 72079

来源：

BIOMARKERS | 1996年 / 1卷 / 02期

关键词：

haemoglobin adducts; herbicides; propanil; fluometuron; agricultural biomonitoring;

D O I：

10.3109/13547509609088681

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aromatic amine herbicides, including propanil, fluometuron, alachlor, trifluralin, and pendimethalin, were examined for their ability to form haemoglobin adducts in rats as potential biomarkers of exposure, Many aromatic amines are known to form haemoglobin adducts via conversion to the nitroso metabolite and binding of this metabolite to cysteinyl groups on haemoglobin, Since red blood cells are long lived, adducts formed with these cells may be reliable biomarkers of exposure with the potential for showing progressive accumulation, Gas chromatographic-mass spectrometric analyses of haemoglobin revealed that adducts were formed in rats treated with the rice herbicide propanil and the cotton herbicide fluometuron, Adducts were not detected with the herbicides alachlor, trifluralin, or pendamethalin.

引用

页码：136 / 140

页数：5

共 22 条

[1] BIOMONITORING OF ANILINE AND NITROBENZENE - HEMOGLOBIN BINDING IN RATS AND ANALYSIS OF ADDUCTS [J].