The nuclear orphan receptor COUP-TFI is required for differentiation of subplate neurons and guidance of thalamocortical axons

被引:151
作者
Zhou, C
Qiu, YH
Pereira, FA
Crair, MC
Tsai, SY
Tsai, MJ
机构
[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA
[2] Baylor Coll Med, Dept Med, Houston, TX 77030 USA
[3] Baylor Coll Med, Div Neurosci, Houston, TX 77030 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1016/S0896-6273(00)81032-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Chicken ovalbumin upstream promotor-transcription factor I (COUP-TFI), an orphan member of the nuclear receptor superfamily, is highly expressed in the developing nervous systems. In the cerebral cortex of Coup-tfl mutants, cortical layer IV was absent due to excessive cell death, a consequence of the failure of thalamocortical projections. Moreover, subplate neurons underwent improper differentiation and premature cell death during corticogenesis. Our results indicate that the subplate neuron defects lead to the failure of guidance and innervation of thalamocortical projections. Thus, our findings demonstrate a critical role of the subplate in early corticothalamic connectivity and confirm the importance of afferent innervation for the survival of layer IV neurons. These results also substantiate COUP-TFI as an important regulator of neuronal development and differentiation.
引用
收藏
页码:847 / 859
页数:13
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