Modeling segmental patterning in Drosophila:: Maternal and gap genes

被引:16
作者
Alves, Filipa [1 ]
Dilao, Rui [1 ]
机构
[1] Univ Tecn Lisboa, Nonlinear Dynam Grp, Dept Phys, Inst Super Tecn, P-1049001 Lisbon, Portugal
关键词
Drosophila segmentation; pattern formation; maternal effect genes; gap genes; genetic regulatory networks; mathematical modeling;
D O I
10.1016/j.jtbi.2005.11.034
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We propose a new mathematical model describing the establishment of maternal and gap proteins segmental patterning along the antero-posterior axis of the Drosophila early embryo. This model is based on experimental data and, without recurring to pre-defined activation thresholds, predicts qualitatively and quantitatively the expression patterns of the maternal and gap proteins, as well as the expression patterns of proteins resulting from mRNA ectopic expression and from some loss-of-function mutations. We conclude that the gap genes segmental patterning and consequent spatial organization of the embryo is determined by three main factors: (1) the initial positioning of the maternal bicoid and tot-so mRNA inside the egg, and subsequent diffusion of the corresponding proteins; (2) the structure of the genetic regulatory network; (3) the role of conservation laws in the establishment of steady and non-uniform spatial distributions of non-diffusing proteins. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:342 / 359
页数:18
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