Peptide coupling of unprotected amino acids through in situ p-nitrophenyl ester formation

被引：39

作者：

Gagnon, P ^{[1
]}

Huang, XC ^{[1
]}

Therrien, E ^{[1
]}

Keillor, JW ^{[1
]}

机构：

[1] Univ Montreal, Dept Chim, Montreal, PQ H3C 3J7, Canada

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 43期

关键词：

D O I：

10.1016/S0040-4039(02)01840-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several series of dipeptides and tripeptides were prepared via an activation-coupling method involving the in situ formation of a p-nitrophenyl ester of an (N-protected) amino acid, followed by coupling with an unprotected amino acid in partially aqueous solutions. The resulting peptide is easily isolated by precipitation. In general, the yields obtained are good to excellent and racemization is minimal. This method is particularly advantageous with respect to its simplicity and lack of obligatory side chain protection/deprotection steps. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：7717 / 7719

页数：3

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