机构:
Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USAUniv Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA
Mello, CC
[1
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Conte, D
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机构:Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA
Conte, D
机构:
[1] Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA
[2] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA
The recent discoveries of RNA interference and related RNA silencing pathways have revolutionized our understanding of gene regulation. RNA interference has been used as a research tool to control the expression of specific genes in numerous experimental organisms and has potential as a therapeutic strategy to reduce the expression of problem genes. At the heart of RNA interference lies a remarkable RNA processing mechanism that is now known to underlie many distinct biological phenomena.