Practical synthesis of amides from in situ generated copper(I) acetylides and sulfonyl azides

被引：255

作者：

Cassidy, Michael P. ^{[1
]}

Raushel, Jessica ^{[1
]}

Fokin, Valery V. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 19期

关键词：

alkynes; azides; copper; oxidation; synthetic methods;

D O I：

10.1002/anie.200503805

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A direct, simple, and efficient route from terminal alkynes to amides is achieved by their copper(I)-catalyzed reaction with sulfonyl azides (see scheme). The reaction proceeds with the in situ generation of copper(I) acetylides and represents a one-step formal oxidative hydration of a triple bond. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3154 / 3157

页数：4

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