Laminin:: the crux of basement membrane assembly

被引:187
作者
Sasaki, T
Fässler, R
Hohenester, E
机构
[1] Univ London Imperial Coll Sci Technol & Med, Blackett Lab, Dept Biol Sci, London SW7 2AZ, England
[2] Max Planck Inst Biochem, Dept Mol Med, D-82152 Martinsried, Germany
基金
英国惠康基金;
关键词
extracellular matrix; embryo development; mutagenesis; structure determination;
D O I
10.1083/jcb.200401058
中图分类号
Q2 [细胞生物学];
学科分类号
071009 [细胞生物学]; 090102 [作物遗传育种];
摘要
Laminin-1 is emerging as the key molecule in early embryonic basement membrane assembly. Here we review recent insights into its functions gained from the synergistic application of genetic and structural methods.
引用
收藏
页码:959 / 963
页数:5
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