The minimal genome concept

被引：79

作者：

Mushegian, A ^{[1
]}

机构：

[1] Akkadix Corp, La Jolla, CA 92037 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1999年 / 9卷 / 06期

关键词：

D O I：

10.1016/S0959-437X(99)00023-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Complete genome sequences are becoming available for a large number of diverse species. Quantification of gene content, of gene family expansion, of orthologous gene conservation, as well as their displacement, are now possible laying the ground for the estimation of the minimal set of proteins sufficient for cellular life. The consensus of computational results suggests a set close to 300 genes. These predictions will be evaluated by engineering of small bacterial genomes.

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页码：709 / 714

页数：6

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